Biothera Research Papers & Presentations

Research demonstrating the safety and efficacy of Biothera compounds is the source of numerous peer-reviewed articles and presentations to scientific forums.

February 2010

Improving Antitumor Activity of Monoclonal Antibodies with Imprime PGG®: A Novel Potentiator of Innate Immunity

A poster presentation at the Molecular Medicine Tri-Conference

San Francisco

October 2009

Antitumor Activity of Soluble Beta-1,3/1,6 Glucans: Structure Matters

Frontiers in Basic Immunology 2009, Bethesda, MD.

Sponsored by the National Cancer Institute.

August 2008

Analysis of Side Chain Lengths of Branched β-1,3-Glucans by Alkaline Degradation.
A poster presentation at the International Carbohydrate Symposium in Oslo, Norway.

March 2008

Mobilization of Hematopoietic Progenitor Cells by Yeast-derived ß-Glucan Requires Activation of Matrix Metalloproteinase-9.

Stem Cells published online Mar 13, 2008; DOI: 10.1634/stemcells.2007-0712.

March 2008

Activation of Human Monocytes with a Yeast-derived Pathogen Associated Molecular Pattern (PAMP), β-glucan.

A poster presentation at Keystone Symposia’s conference on Innate Immunity: Signaling Mechanisms.

February 2008

Yeast-Derived β-Glucan Augments the Therapeutic Efficacy Mediated by Anti-Vascular Endothelial Growth Factor Monoclonal Antibody in Human Carcinoma Xenograft Models.

Clinical Cancer Research 2008;1239 14(4) February 15, 2008.

August 2007
Combined Yeast ß-Glucan and Antitumor Monoclonal Antibody Therapy Requires C5a-Mediated Neutrophil Chemotaxis via Regulation of Decay-Accelerating Factor CD55.

Cancer Research. 2007 67: 7421-7430.

December 2006

β-Glucan is a Fungal Determinant for Adhesion-Dependent Human Neutrophil Functions.

Journal of Immunology. Dec 2006; 177: 8667 - 8675.

August 2006
Yeast ß-Glucan Amplifies Phagocyte Killing of iC3b-Opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-Kinase Pathway.
The Journal of Immunology. 2006 Aug 1;177(3):1661-9

April 2006
The Effect of PGG-Beta-Glucan on Neutrophil Chemotaxis in Vivo.
Journal of Leukocyte Biology. 2006 Apr; 79 (4:667-75). Epub 2006 Jan 13.

June 2005
C5a-Mediated Leukotriene B4-Amplified Neutrophil Chemotaxis is Essential in Tumor Immunotherapy Facilitated by Anti-Tumor Monoclonal Antibody and ß-Glucan.
The Journal of Immunology. 2005 174:7050-7056

September 2004
ß-Glucan Affects Leukocyte Navigation in a Complex Chemotactic Gradient.
Surgery. 2004: 136:384-89

March 2004
Complement Function in Monoclonal Antibody-Mediated Cancer Immunotherapy.
Review published in Trends in Immunology.

December 2003
ß-Glucan Functions as an Adjuvant for Monoclonal Antibody Immunotherapy by Recruiting Tumoricidal Granulocytes as Killer Cells.
Cancer Research. 63, 9023-9031, Dec. 15, 2003

March 2003
Anthrax-Protective Effects of Yeast Beta 1,3 Glucans.
Medscape General Medicine 5(1), 2003. © 2003 Medscape.